Summary of the Recent Literature on Bipolar Disorder
نویسنده
چکیده
Acute Mania Quetiapine XR (FDA approved for the treatment of acute mania) monotherapy has been shown to be more effective than placebo in treating acute mania with improvement starting at day 4. Aripiprazole adjunctive therapy was more effective than placebo adjunctive therapy in treating manic symptoms in BD manic patients with inadequate response to lithium or divalproex in a 6 week trial. Olanzapine plus carbamazepine was no more effective than placebo and carbamazepine in BD patients with manic or mixed episodes. In light of the fact that the combination was associated with significantly higher rates of lipid abnormalities and weight gain, the combination is not recommended.
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